4/6/2023 0 Comments Chronological age pearsonEvaluating the durability of the immune response induced by the SARS-CoV-2 infection, particularly the humoral immune response, is critical for understanding the pathogenesis of SARS-CoV-2 and evaluating the protection efficiency of the current vaccines. However, the duration of immunological protection at individual level still necessitates further investigation. 1 Shortly after the virus spread on a global scale, vaccine production and trials were started by several multinational pharma companies and the vaccine produced by Pfizer/BioNTech was the first to be authorized for emergency use. The SARS-CoV-2 pandemic is still ongoing with more than 464 million infections and up to six million deaths. Keywords: SARS-CoV-2, antibody titer, anti-spike IgG antibody, Pfizer vaccine, AstraZeneca vaccine These data will help to evaluate the need for further COVID-19 vaccine doses and to what extent a two-dose regimen will protect vaccinated individuals. Individuals who received mixed types of vaccines had significantly better response than Pfizer vaccine alone.Ĭonclusion: The current study investigates the status of humoral responses in different age groups, in terms of antibody measurements. The IgG levels in both serum and saliva were higher after three months and start to wane after six months. Results: IgG levels varied with age groups with the highest concentration in the age group 19– 29 years, but the age group (≥ 50) had the lowest IgG concentration. We employed a specific ELISA assay in plasma and saliva of fully vaccinated individuals. Methods: A total of 141 healthy volunteers were recruited to our study blood (n=63) and the saliva samples (n=78) and were collected from fully vaccinated individuals in Riyadh city. Moreover, we analyze the current state of immune response in terms of antibody responses in thepopulation postvaccination using homogenous or hetrogenous vaccine regimen. Also, to evaluate the continuity of specific IgG levels and compare the titers in individuals who have been received two doses of the matched and mixed vaccines, including Pfizer and AstraZeneca against SARS-CoV-2 during the period of three to six months. However, with the emergence of new virus variants, it is critical to determine the longevity and the protection efficiency provided by the current authorized vaccines.Īim: The aims of this study are to provide data about the magnitude of immune responses in individuals fully vaccinated against COVID-19 in Riyadh province of Saudi Arabia. Vaccination campaigns undertaken by several countries have resulted in a notable decrease in hospitalization and deaths. Ayman Mubarak, 1 Saeedah Almutairi, 1 Abulrahman D Al-Dhabbah, 1 Shaha Y Aldabas, 1 Rauf Bhat, 1 Mahfoudh M Alqoufail, 1 Mostafa A Abdel-Maksoud, 1 Taghreed N Almanaa, 1 Mohamed A Farrag, 1 Wael Alturaiki 2ġDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia 2Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Majmaah, 11952, Saudi ArabiaĬorrespondence: Wael Alturaiki, Email īackground: SARS-CoV-2 pandemic continues to threaten the human population with millions of infections and deaths worldwide.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |